A PLATFORM TRIAL APPROACH TO PROOF-OF-CONCEPT (POC) STUDIES IN AUTISM SPECTRUM DISORDER: AUTISM SPECTRUM POC INITIATIVE (ASPI)

A platform trial approach to proof-of-concept (POC) studies in autism spectrum disorder: Autism spectrum POC initiative (ASPI)

Background: Over the past decade, autism spectrum disorder (ASD) research has blossomed, and multiple clinical trials have tested potential interventions, with varying results and no clear demonstration of efficacy.Lack of clarity concerning appropriate biological mechanisms to target and lack of sensitive, objective tools to identify subgroups and

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Heat Transfer in a Drilling Fluid with Geothermal Applications

The effects of various conditions on the fluid flow, particle migration and heat transfer in non-linear fluids encountered in drilling and geothermal applications are studied.We assume that the drilling fluid is a suspension composed of various substances, behaving as a non-linear complex fluid, where the effects of particle volume fraction, shear

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Improving the ductility and toughness of nano-TiC/AZ61 composite by optimizing bimodal grain microstructure via extrusion speed

In this study, the nano-TiC/AZ61 composites with different heterogeneous bimodal grain (HBG) structures and uniform structure are obtained by regulating the extrusion speed.The effect of HBG structure on the mechanical properties of the composites is investigated.The increasing ductility and toughening mechanism of HBG magnesium matrix composites a

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Retractable Contracts

In calculi for modelling 2004 hyundai santa fe catalytic converter communication protocols, internal and external choices play dual roles.Two external choices can be viewed naturally as dual too, as they represent an agreement between the communicating parties.If the interaction fails, the past agreements are good candidates as points where to dosa

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